Targeted Deletion of the Kynurenine Aminotransferase II Gene Reveals a Critical Role of Endogenous Kynurenic Acid in the Regulation of Synaptic Transmission via 7 Nicotinic Receptors in the Hippocampus
نویسندگان
چکیده
Manickavasagon Alkondon,1* Edna F. R. Pereira,1* Ping Yu,2* Emerson Z. Arruda,1,3* Luis E. F. Almeida,1 Paolo Guidetti,4 William P. Fawcett,1 Michael T. Sapko,4 William R. Randall,1 Robert Schwarcz,1,4 Danilo A. Tagle,2 and Edson X. Albuquerque1,3 1Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, 2Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, 3Departamento de Farmacologia Básica e Clı́nica, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21944, Brazil, and 4Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228
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In the mouse hippocampus normal levels of kynurenic acid (KYNA), a neuroactive metabolite synthesized in astrocytes primarily by kynurenine aminotransferase II (KAT II)-catalyzed transamination of L-kynurenine, maintain a degree of tonic inhibition of 7 nicotinic acetylcholine receptors (nAChRs). The present in vitro study was designed to test the hypothesis that 7 nAChR activity decreases when...
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In the mouse hippocampus normal levels of kynurenic acid (KYNA), a neuroactive metabolite synthesized in astrocytes primarily by kynurenine aminotransferase II (KAT II)-catalyzed transamination of L-kynurenine, maintain a degree of tonic inhibition of α7 nicotinic acetylcholine receptors (nAChRs). The present in vitro study was designed to test the hypothesis that α7 nAChR activity decreases wh...
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